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Osteoarthritis (OA), also known as degenerative joint disease or osteoarthrosis,is the most common form of arthritis. OA occurs when cartilage in the joints wearsdown over time. We used the GSE1919 series to identify potential genes that correlatedto OA. The aim of our study was to obtain a molecular signature of OA throughthe regulation network based on differentially expressed genes. From the resultof regulation network construction in OA, a number of transcription factors (TFs)and pathways closely related to OA were linked by our method. Peroxisome proliferator-activatedreceptor γ also arises as hub nodes in our transcriptome network and certain TFscontaining CEBPD, EGR2 and ETS2 were shown to be related to OA by a previous study.

Obtain osteoarthritis related molecular signature genes through regulation network