English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Metastasis is a major cause of mortality among lung cancer patients. In a previous high-throughput screening of 20,000 compounds to identify inhibitors of cancer cell migration, 4-methyl-3-nitrobenzoic acid was found to inhibit the migration of nine tumor cell lines. The present study used the human non-small cell lung cancer cell (NSCLC) treatment with 4-methyl-3-nitrobenzoic acid significantly inhibited epithelial growth factor (EGF)-induced chemotaxis and chemokinesis of cancer cells in NSCLC cells. The defect in chemotaxis is likely due to the impairment in EGF-induced cofilin phosphorylation and actin polymerization. Furthermore, EGF-induced cell adhesion, which is another key factor in cell migration, was also inhibited. Taken together, these results suggest that 4-methyl-3-nitrobenzoic acid is a potent inhibitor of cancer cell chemotaxis and may be developed into a novel antimetastasis drug.

Effect of 4-methyl-3-nitrobenzoic acid on non‑small cell lung cancer cell migration