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Previously, we demonstrated that follicle stimulating hormone (FSH) enhancedVEGF expression and facilitated ovarian cancer angiogenesis via the PI3K/AKT signalingpathway. In this study, we further investigated the involvement of microRNA-27a:ZBTB10‑specificity protein pathway in the mechanism of FSH-induced VEGF, Cox2and survivin expression. Treatment with FSH resulted in significant increase inthe expression of VEGF, Cox2, survivin, Sp1 proteins and microRNA-27a in a dose-dependentmanner, whereas reverse protein expression pattern was observed in ZBTB10. Downregulationof microRNA-27a using antisense microRNA-27a blocked FSH-induced VEGF, Cox2 andsurvivin expression. Overexpression of ZBTB10 also attenuated the FSH-inducedexpression of these molecules. The enhanced expression of VEGF, Cox2 and survivinwas also abolished by knocking down Sp1 using small interfering RNA. Collectively,these results indicated that stimulation of ovarian cancer cell VEGF, Cox2 andsurvivin expression by FSH involves the microRNA‑27a: ZBTB10-specificity proteinpathway.

international journal of oncology

The microRNA-27a: ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2 and survivin expression in ovarian epithelial cancer cells