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The incidence of cervical adenocarcinoma, which accounts for 10-20% of allcervical cancers, has increased continuously in developed countries during thelast two decades, unlike squamous cell cervical carcinoma. This increasing trend,noted particularly among women under the age of 40 years, has occurred despiteextensive cytological Pap smear screening. A deeper understanding of the etiologyof cervical adenocarcinoma, better preventive measures and reliable prognosticmarkers are urgently needed. The human leucine-rich repeats and immunoglobulin-likedomains (LRIG) gene family includes: LRIG1, LRIG2 and LRIG3. LRIG expression hasproven to be of prognostic value in different types of human cancers, includingbreast cancer, early stage invasive squamous cervical cancer, cutaneous squamouscell carcinoma, oligodendroglioma and astrocytoma. LRIG1 functions as a tumorsuppressor, while less is known about the functions of LRIG2 and LRIG3. This studyevaluated the expression of the three LRIG proteins in tumor specimens from 86women with pure cervical adenocarcinoma by immunohistochemistry. Possible correlationsbetween LRIG expression and known prognostic factors, including human papillomavirus(HPV) status, FIGO stage and histology were investigated. Patient survival datawere collected retrospectively and the possible prognostic value of LRIG proteinexpression was investigated. High staining intensity of LRIG1 and high fractionof LRIG3-positive cells were significantly associated with patient survival, andpositive correlations were found between LRIG1 and LRIG3 staining intensity andHPV status. Thus, the LRIG proteins may be important determinants of cervicaladenocarcinoma progression and their diagnostic and prognostic potential shouldbe studied further.

Expression of LRIG1 and LRIG3 correlates with human papillomavirus status and patient survival in cervical adenocarcinoma