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The present study investigates extracts of Neuolaena lobata, an anti-protozoanethnomedicinal plant of the Maya, regarding its anti-neoplastic properties. Firstly,extracts of increasing polarity were tested in HL-60 cells analyzing inhibitionof cell proliferation and apoptosis induction. Secondly, the most active extractwas further tested in anaplastic large cell lymphoma (ALCL) cell lines of humanand mouse origin. The dichloromethane extract inhibited proliferation of HL-60,human and mouse ALCL cells with an IC50 of ~2.5, 3.7 and 2.4 µg/ml, respectivelyand arrested cells in the G2/M phase. The extract induced the checkpoint kinasesChk1 and Chk2 and perturbed the orchestrated expression of the Cdc25 family ofcell cycle phosphatases which was paralleled by the activation of p53, p21 anddownregulation of c-Myc. Importantly, the expression of NPM/ALK and its effectorJunB were drastically decreased, which correlated with the activation of caspase3. Subsequently also platelet derived growth factor receptor β was downregulated,which was recently shown to be transcriptionally controlled by JunB synergizingwith ALK in ALCL development. We show that a traditional healing plant extractdownregulates various oncogenes, induces tumor suppressors, inhibits cell proliferationand triggers apoptosis of malignant cells. The discovery of the 'Active Principle(s)'is warranted.

international journal of oncology

The dichloromethane extract of the ethnomedicinal plant Neurolaena lobata inhibits NPM/ALK expression which is causal for anaplastic large cell lymphomagenesis