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miRNAs are small, non-coding RNAs that play important roles in various biologicalprocesses. The aims of our study were to investigate whether cell-free miRNAscan be measured in urine samples and might be an accurate biomarker of bladdercancer. Datasets of GSE20418 and GSE19717 were used for analysis, and two miRNAs,miR-145 and miR-200a, were selected for study. A total of 207 patients with primarytransitional cell carcinoma of the urinary bladder and 144 healthy normal controlswere enrolled. Using quantitative PCR, the levels of miR-145 and miR-200a in urinewere measured and compared with the clinicopathological features of bladder cancer.According to our experiments, cell-free miRNAs were present in urine and werestable. Assessment of miR-145 levels was able to distinguish bladder cancer patientsfrom non-cancer controls (77.8% sensitivity and 61.1% specificity for NMIBC, AUC0.729; 84.1 and 61.1% for MIBC, respectively, AUC 0.790) and showed good correlationwith grade (p=0.048). In addition, miR-200a was shown to be an independent predictorof NMIBC recurrence by multivariate analysis (OR 0.449, 95% CI 0.239‑0.842, p=0.013).A higher risk of recurrence was observed among patients with a lower miR-200alevel compared to patients with higher miR-200a levels (log-rank test, p=0.040).Urinary cell-free miRNAs show promise as noninvasive biomarkers for diagnosisand recurrence of bladder cancer.

Cell-free microRNAs in urine as diagnostic and prognostic biomarkers of bladder cancer