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Proteases, particularly serine proteases like dipeptidyl peptidase 4 (DP4)and fibroblast activation protein (FAP), play an important role in cancer invasionand angiogenesis. Aberrant expression of DP4 and FAP is associated with numerouscancers, including breast and epithelial ovarian carcinoma. We investigated themRNA levels, protein expression and enzyme activity of the structural homologsDP8 and DP9, in addition to DP4 and FAP, in three breast carcinoma (MDA-MB-231,MDA-MB-453, MCF-7), three epithelial ovarian carcinoma (EOC) (OVCA-432, OVCA-429,SKOV3), 293T and HeLa cell lines. In addition, DP2 and prolyl endopeptidase (PEP)mRNA and enzyme levels were measured and compared in each cell line. Ubiquitousbut differential expression of DP8 and DP9 mRNA and protein was observed acrossall cell lines. Relative to EOC, DP8 protein was lower in the breast carcinomacell lines (p=0.057), suggesting that DP8 may play differing roles in differentcancer cell types. A strong, negative, non-reciprocal relationship was identifiedbetween DP9 protein and DP4 mRNA (r=-0.903, p=0.002) and protein (r=-0.810, p=0.015).This suggests that DP4 expression plays an important role in the post-transcriptionalregulation of DP9 in breast and ovarian cancer cell lines. Overall, this studysuggests a potential role for DP8 and DP9 in breast and ovarian cancer and furtherinvestigations in this area are required.

Expression profiling of dipeptidyl peptidase 8 and 9 in breast and ovarian carcinoma cell lines