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The poliovirus receptor CD155, is essential for poliovirus to infect andinduce death in neural cells. Recently, CD155 has been shown to be selectivelyexpressed on certain types of tumor cells originating from the neural crest, includingmalignant glioma and neuroblastoma. However, the expression pattern of CD155 insoft tissue sarcoma has not been examined. Therefore, we first examined CD155expression in sarcoma cell lines, and found the expression of both CD155 mRNAand protein in 12 soft and bone tissue sarcoma cell lines. Furthermore, we examinedthe effect of live attenuated poliovirus (LAPV) on 6 bone and soft tissue sarcomacell lines in vitro, and found that LAPV induced apoptosis by activating caspases 7and 3 in all of these cell lines. Furthermore, in BALB/c nu/nu mice xenotransplantedwith HT1080 fibrosarcoma cells, administration of live attenuated poliovirus causedgrowth suppression of the tumors. These results suggest that oncolytic therapyusing a LAPV may represent a new option for the treatment of bone and soft tissuesarcomas.

Oncolytic virotherapy for human bone and soft tissue sarcomas using live attenuated poliovirus