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Recent studies implicated IKKε in the pathogenesis of many human cancersby promoting cell proliferation, increasing tumor angiogenesis and metastasis,and generating resistance to cell apoptosis. However, whether IKKε can influencethe invasive ability and proliferation of glioma cells remains largely unknown.In this study, we showed that overexpression of IKKε is positively correlatedto glioma pathological grade, suggesting that IKKε plays a role in tumor progression,rather than tumor initiation. Targeted knockdown of IKKε in human glioma cellsusing siRNA, was associated with inhibition of cell growth, cell cycle arrestand decreased cell invasion; however, notable apoptosis was not observed. Furthermore,we demonstrated that transposition of NF-κB p65 resulted in the alteration ofthese phenotypes. Tumor growth was attenuated in established subcutaneous gliomasin nude mice treated with IKKε siRNA in vivo. Collectively, our results suggestthat deregulation of IKKε plays a pivotal role in the uncontrolled proliferationand malignant invasion of glioma cells in vitro and in vivo by targeting NF-κB.Silencing of IKKε using synthetic siRNAs may offer a novel therapeutic strategyfor the treatment of glioma.

Silencing of IKKε using siRNA inhibits proliferation and invasion of glioma cells in vitro and in vivo