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Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family,which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene.In this study, we identified miR-892a as a negative regulator of CYP1A1 expression.Luciferase assays revealed a sequence in the 3'-untranslated region of CYP1A1that displayed a perfect match with miR-892a, and revealed that this sequencewas a specific miR-892a target site. The overexpression of miR‑892a inhibitedthe expression of the CYP1A1 protein, and the miR‑892a antagonist increased CYP1A1expression. Of note, benzo(a)pyrene, a major inducer of CYP1A1 transcription,decreased the expression of miR-892a. Moreover, the miR-892a-induced CYP1A1 repressioninhibited the benzo(a)pyrene-mediated decrease in cell viability. These data provideinsight into the CYP1A1 regulatory network.

CYP1A1 is a target of miR-892a-mediated post-transcriptional repression