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Aiming to identify novel sero-diagnostic markers for neuroendocrine carcinomasof the lung, the two-dimensional gel electrophoresis-immunoblot method was usedto analyze tumor-associated autoantibodies in patients with small cell lung carcinoma(SCLC) and large cell neuroendocrine carcinoma (LCNEC). Several autoantigens wererevealed and anti-HuC autoantibody was detected only in sera of SCLC patients.Since Hu family proteins including HuC are well-known causes of paraneoplasticencephalomyelitis/sensory neuronopathy (PEM/SN), the expression of HuC as wellas HuD mRNAs and their proteins was studied in 11 lung cancer cell lines. Theexpression of HuC and HuD mRNAs and proteins was only detected in SCLC- and LCNEC-derivedcells. To validate the existence of anti-HuC and -HuD auto-antibodies, we studieda large number of sera including those from lung cancer patients employing dotblot analysis. Anti-HuC and -HuD autoantibodies were detected only in SCLC caseswith or without PEM/SN, and not in the sera of LCNEC patients. The mechanism leadingto different anti-HuC and -HuD autoantibody production between SCLC and LCNECis unclear; however, the results from the present and previous studies suggestthat anti-HuC and -HuD auto-antibodies are novel differential sero-diagnosticmarkers for SCLC from LCNEC.

international journal of oncology

Anti-HuC and -HuD autoantibodies are differential sero-diagnostic markers for small cell carcinoma from large cell neuroendocrine carcinoma of the lung