English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The prognosis of oral squamous cell carcinoma (OSCC) is significantly dependenton the existence of cervical lymph node metastasis (LNM), with the overall survivalrate being much lower in patients with LNM. Primary causes and molecular mechanismsof LNM are still largely unclear. We hypothesized that factors related with cancerprogress and/or prognosis in OSCC are revealed by genome-wide investigation ofDNA copy number aberrations (CNAs). In order to find biomarkers for occult LNMof OSCC, we comprehensively investigated genomic DNAs from 60 OSCC patients usingAffymetrix mapping arrays and statistically analyzed correlations between CNAsof genes and the presence of occult LNM in the patients. The genome-wide CNA studyindicated significant correlations between the presence of occult LNM and CNAsof certain genes. Through a literature survey, we narrowed down the candidatesand focused on loss of NKX3-1, which is a homeodomain-containing transcriptionfactor. NKX3-1 is known as a tumor suppressor gene in prostate cancer but hasnever been reported in OSCC. Quantitative RT-PCR and immunohistochemistry (IHC)analyses also showed significantly lower expression of NKX3-1 in the cases withoccult LNM, which was further validated by IHC analysis in independent cases.The survival analyses indicated that NKX3-1 loss is a significant risk factorto decrease the disease-free survival (DFS) and the overall survival (OS) rates.This is the first time that the significant association of NKX3-1 loss and occultLNM was indicated in OSCC. The present results suggest that loss of NKX3-1 maybe a potential biomarker for occult LNM of OSCC.

Loss of NKX3-1 as a potential marker for an increased risk of occult lymph node metastasis and poor prognosis in oral squamous cell carcinoma