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Breast cancer is one of the most common malignant tumors and the leadingcause of mortality among women. In this study, we propose a human stem cell transplantationstrategy, an important method for treating various cancers, as a potential breastcancer therapy. To this end, we used human amniotic membrane-derived epithelialstem cells (hAECs) as a cell source for performing human stem cell transplantation.hAECs have multipotent differentiation abilities and possess high proliferativepotential. We transplanted hAECs into female BALB/c nude mice bearing tumors originatingfrom MDA-MB-231 breast cancer cells. Co-culturred hAECs and MDA-MB-231 cells ata ratio of 1:4 or 1:8 (tumor cells to stem cells) inhibited breast cancer cellgrowth by 67.29 and 67.33%, respectively. In the xenograft mouse model, tumorvolumes were significantly decreased by 5-flurouracil (5-FU) treatment and twodifferent ratios of hAECs (1:4 and 1:8) by 84.33, 73.88 and 56.89%, respectively.Treatment of nude mice with hAECs (1:4) produced remarkable antitumor effectswithout any side-effects (e.g., weight loss, death and bruising) compared to themice that received only 5-FU treatment. Tumor progression was significantly reducedby hAEC treatment compared to the xenograft model. On the other hand, breast tissues(e.g., the epidermis, dermis and reticular layer) appeared to be well-maintainedfollowing treatment with hAECs. Taken together, these results provide strong evidencethat hAECs can be used as a safe and effective cancer-targeting cytotherapy fortreating breast cancer.

international journal of oncology

Human amniotic membrane-derived epithelial stem cells display anticancer activity in BALB/c female nude mice bearing disseminated breast cancer xenografts