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A novel IgG1, κ mouse monoclonal antibody (clone 1E8.33) to human procollagen11A1 has been generated. This antibody is poorly mutated, essentially in germline configuration; its complementarity determining regions (CDRs) are especiallyrich in tyrosine and serine residues. The epitope recognized is encompassed inthe YNYGTMESYQTEAPR amino acid stretch within the variable region of human procollagen11A1. Human procollagens 5A1 and 11A1 are very similar. However, this antibodydoes not cross-react with human procollagen 5A1. In human breast tumors, onlythe activated peritumoral myofibroblasts show a strong intracytoplasmic stainingwith this antibody. As procollagen 11A1 is overexpressed in the stroma of humantumors with desmoplastic reaction, this antibody represents a valuable tool fordiagnostic purposes.

Characterization of a novel mouse monoclonal antibody, clone 1E8.33, highly specific for human procollagen 11A1, a tumor-associated stromal component