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The most common therapeutic approach for many cancers is chemotherapy. However,many patients relapse after treatment due to the development of chemoresistance.Recently, targeted therapies represent novel approaches to destroy cancer cells.The PI3K/PTEN/AKT pathway is a key signaling pathway involved in the regulationof cell growth. Dysregulated signaling of this pathway may be associated withactivating mutations of PI3K-related genes. Analyses of these mutations revealthat they increase the PI3K signal, stimulate downstream Akt signaling, promotegrowth factor-independent growth and increase cell invasion and metastasis. Inthis review, we summarize the PI3K/PTEN/AKT pathway genetic alterations in cancerand their potential clinical applications.

Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (Review)