English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Polymorphous low-grade adenocarcinoma (PLGA) is a malignancy predominantlyoriginating from the minor salivary glands. The molecular events underlying thepathogenesis of PLGA is poorly understood and no recurrent genetic aberrationshave so far been identified. We used genome-wide, high-resolution aCGH analysisto explore genomic imbalances in 9 cases of PLGA. Because of the well-known morphologicsimilarities between PLGA and adenoid cystic carcinoma (ACC) we also analyzedall tumors for expression of the recently identified ACC-associated MYB-NFIB genefusion. aCGH analysis revealed that the PLGA genome contains comparatively fewcopy number alterations (CNAs). Gains/losses of whole chromosomes or chromosomearms were more than twice as common as partial CNAs. Two cases showed gain ofchromosome 8 and one case each gain of chromosome 9, loss of chromosome 22 andloss of the Y chromosome. One case showed loss of the entire 6q arm and one casean interstitial deletion of a 33-Mb segment within 6q22.1-q24.3. This region containsthe MYB oncogene and the candidate tumor suppressor gene PLAGL1. RT-PCR analysisrevealed that one of the 9 PLGAs expressed the ACC-associated MYB-NFIB gene fusion,illustrating the diagnostic difficulties associated with the diagnosis of thesemorphologically partly overlapping entities. Taken together, our findings indicatethat the PLGA genome is genetically stable and contains comparatively few CNAswhich is in line with the clinical observation that PLGA is a slow-growing, low-gradecarcinoma with low metastatic potential.

Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck