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Understanding the mechanisms of thymus regeneration is necessary for designingstrategies to enhance host immunity when immune function is suppressed due toT cell depletion. In this study, expressed sequence tag (EST) analysis was performedfollowing generation of a regenerating thymus cDNA library to identify genes expressedin thymus regeneration. A total of 1,000 ESTs were analyzed, of which 770 (77%)matched to known genes, 178 matched to unknown genes (17.8%) and 52 (5.2%) didnot match any known sequences. The ESTs matched to known genes were grouped intoeight functional categories: gene/protein synthesis (28%), metabolism (24%), cellsignaling and communication (17%), cell structure and motility (6%), cell/organismdefense and homeostasis (6%), cell division (3%), cell death/apoptosis (2%), andunclassified genes (14%). Based on the data of RT-PCR analysis, the expressionof TLP, E2IG2, pincher, Paip2, TGF-β1, 4-1BB and laminin α3 genes was increasedduring thymus regeneration. These results provide extensive molecular information,for the first time, on thymus regeneration indicating that the regenerating thymuscDNA library may be a useful source for identifying various genes expressed duringthymus regeneration.

international journal of molecular medicine

Identification and analysis of expressed genes using a cDNA library from rat thymus during regeneration following cyclophosphamide-induced T cell depletion