English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Myocardial stunning, which is closely related to myocardial edema, is asevere complication that may occur following cardiac surgery. In this study, weexamined the expression of aquaporin 1 (AQP1) and Connexin 43 (Cx43) followingcardiopulmonary bypass (CPB) surgery in goats. We assessed myocardial muscle tissuewater content according to changes in dry-wet weight. Our results showed thatAQP1 expression and myocardial muscle tissue water content increased significantly6 h after CPB surgery, reaching peak levels 48 h after surgery; additionally,the protein expression of Cx43 was inversely correlated with AQP1 expression.Overexpression of AQP1 during CPB surgery enhanced the degree of myocardial edema,whereas the addition of water channel protein inhibitor Hg2+ in cold crystalloidcardioplegia and knockdown of AQP1 during surgery weakened the degree of myocardialedema. These findings revealed that the severity of myocardial edema after CPBsurgery is correlated with AQP1 protein expression levels, suggesting the importantrole played by AQP1 protein in the regulation of Cx43 in the pathological progressionof myocardial edema.

Aquaporin 1 plays an important role in myocardial edema caused by cardiopulmonary bypass surgery in goat