English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The ATP-binding membrane cassette transporter A1 (ABCA1) plays a protectiverole in the development of atherosclerosis for the reverse cholesterol transportprocess. Epigallocatechin-3-gallate (EGCG), which exists abundantly in green tea,exerts an anti-atherosclerotic effect via anti-inflammatory and metabolic regulationactivities. Many genes and proteins related to lipid metabolism are involved inthe lowering cholesterol effects of EGCG. However, effects of EGCG on ABCA1 haverarely been described. In the study presented here, we found that exposure ofmacrophage foam cells to TNF-α results in a downregulation of ABCA1 and a decreasein cholesterol efflux to apoA1, which is attenuated by pretreatment with EGCG.Moreover, rather than activating the Liver X receptor (LXR) pathway, inhibitionof the TNF-α-induced nuclear factor-κB (NF-κB) activity is detected with EGCGtreatment in cells. In order to inhibit the NF-κB activity, EGCG can promote thedissociation of the nuclear factor E2-related factor 2 (Nrf2)-Kelch-like ECH-associatedprotein 1 (Keap1) complex; when the released Nrf2 translocates to the nucleusand activates the transcription of genes containing an ARE element inhibitionof NF-κB occurs and Keap1 is separated from the complex to directly interact withIKKβ and thus represses NF-κB function. These results provide novel insight intothe anti-inflammatory effects of EGCG, as well as the identification of a novelpotential therapeutic role for the prevention of atherosclerosis.

Epigallocatechin-3-gallate prevents TNF-α-induced NF-κB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells