English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Traditional natural plants have been used throughout the world for theirantidiabetic effects. The aim of the present study was to investigate the stimulatingactivity of a polysaccharide extract derived from T. aestivum sprout (TASP) oninsulin secretion in vitro using the RIN-5F pancreatic β-cell line and rat pancreaticislets. In these experiments, TASP (0.1 to 2 mg/ml) augmented glucose-stimulatedinsulin secretion in a dose-dependent manner in the presence of a stimulatoryglucose concentration (16.7 mM), but not of a basal concentration (1.1 mM). AlthoughTASP failed to enhance the high K+-induced insulin secretion, the insulinotropiceffect of TASP was significantly inhibited by diazoxide, an opener of ATP-sensitiveK+ channel blocking insulin release. TASP potentiated the insulin secretion inducedby other secretagogues, such as IBMX and tolbutamide. Moreover, glucose-derivedblood insulin levels were significantly elevated by oral administration of TASPto mice, similarly to antidiabetic drugs. We also demonstrated that TASP significantlyincreased glucose-induced 45Ca2+ uptake and proinsulin mRNA expression in ratislets. Overall, our results suggest that TASP has a stimulating effect on insulinsecretion and production in pancreatic β-cells via K+ channel closure and calciuminflux. These results suggest that TASP may be useful as a candidate for the therapyof diabetes mellitus.

Polysaccharide isolated from Triticum aestivum stimulates insulin release from pancreatic cells via the ATP-sensitive K+ channel