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Serum undercarboxylated osteocalcin (s-ucOC) is a marker for vitamin K metabolism(deficiency). The aim of this study was to investigate the serum levels of ucOCin patients with bilateral knee osteoarthritis (K-OA), and the correlation betweenucOC and other biomarkers for K-OA. A total of 25 patients (22 women, 3 men, meanage 76.0±7.8, range 54-88 years, mean BMI 24.9±4.7) with a Kellgren-Lawrence gradeof 3 or 4 for bilateral knee were enrolled in this study. The levels of s-ucOCand other biomarkers were measured. The levels of s-ucOC (5.66±4.70 ng/ml) aswell as other cartilage metabolism markers, were elevated in the patients; however,bone metabolism markers were within the normal ranges. Of interest, there wasa significant correlation between s-ucOC and serum hyaluronan (a marker for synovitis)(P&lt;0.05). Our findings suggest that vitamin K metabolism may be associatedwith synovitis in patients with K-OA, and s-ucOC could be a biomarker for K-OA.

Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis