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The PI3K/Akt pathway, a critical mediator of cell survival, is suppressedin cerebral ischemia/reperfusion (I/R) injury; therefore, it is a major focusin treatment of ischemic stroke. Acupuncture has long been used in China to clinicallytreat stroke. However, the precise mechanism of its neuroprotective activitiesremains largely unknown. Using a focal cerebral I/R injured rat model, in thepresent study we evaluated the in vivo therapeutic efficacy of electroacupunctureand investigated the underlying molecular mechanisms. We found that electroacupunctureat Quchi (LI11) and Zusanli (ST36) acupoints on the contralateral paralyzed limbsignificantly improved neurological deficits and cerebral infarction. In addition,electroacupuncture profoundly activated PI3K/Akt signaling in ischemic cerebraltissues. Consequently, the upregulatory effect of electroacupuncture on PI3K/Aktactivation resulted in the inhibition of cerebral cell apoptosis. Moreover, electroacupunctureincreased the serum secretion levels of the PI3K activators BDNF and GDNF, aswell as upregulated the anti-apoptotic Bcl-2/Bax ratio in ischemic cerebrum. Ourdata suggest that electroacupuncture at Quchi and Zusanli acupoints exerts neuroprotectivefunction in ischemic stroke via activation of the PI3K/Akt pathway.

international journal of molecular medicine

Electroacupuncture at the Quchi and Zusanli acupoints exerts neuroprotective role in cerebral ischemia-reperfusion injured rats via activation of the PI3K/Akt pathway