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Retinitis pigmentosa (RP) is an inherited retinal disease caused by the degeneration of photoreceptors and retinal pigment epithelium cells within the eye. The present study aimed to evaluate the effectiveness of multicolor imaging as a novel technique for the depiction of morphological features in the macular area of patients with RP. Additionally, the correlation between the size of the macular-sparing area and the best corrected visual acuity (BCVA), central visual field function and subfoveal choroidal thickness (SFCT) was analyzed. A total of 25 individuals with RP (n=50 eyes) and 35 healthy individuals (n=70 eyes) were enrolled in the current study. Images of the macular area were captured using multicolor imaging and traditional fundus photography, and their ability to depict retinal features was compared. The size of the macular-sparing area in patients with RP was measured using built-in measurement software programs. The correlations between the macular-sparing area and the BCVA, visual field and SFCT were analyzed using a Spearman's rank correlation test. The results demonstrated that multicolor imaging revealed clinical features of the macular area in greater detail than traditional fundus photography irrespective of whether the patient also had complications, including cataracts and epiretinal membranes. Multicolor imaging clearly defined the borders of the macular-sparing area corresponding to the relatively intact outer retinal structures on optical coherence tomography images, particularly the status of the ellipsoid zone and external limiting membrane. There was a significant positive correlation between the macular-sparing area and BCVA (r=-0.631; P&lt;0.001), and the visual field in terms of MD (r=0.402; P&lt;0.05) and PSD (r=0.595; P&lt;0.001), however, there was not a statistically significant correlation between the macular-sparing area and SFCT. The present study demonstrated that multicolor imaging is capable of detecting macular changes and complications in patients with RP. Multicolor imaging may be particularly useful in assessing the detailed characteristics of the macular-sparing area, as this appears to be associated with visual function.

experimental and therapeutic medicine

Morphologic characteristics and clinical significance of the macular‑sparing area in patients with retinitis pigmentosa as revealed by multicolor imaging