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Diabetic nephropathy is a major complication of diabetes mellitus (DM). Recent studies suggest that immunological mechanisms have a key role in the pathogenesis of DM, therefore these mechanisms may be important targets for diabetes therapy. The present study evaluated the effects of anti-α 1 -adrenergic receptor antibody (α 1 -R Ab) mediation and doxazosin treatment in a rat model of DM. It was observed that levels of 24-h urinary protein, serum creatinine and transforming growth factor-β 1 in DM were significantly increased after α 1 -R Ab mediation (all P&lt;0.05). In addition, electron microscopy identified severe damage in the renal tissue microstructures of DM rats following α 1 -R Ab mediation, while only mild abnormalities were observed in that of healthy rats mediated with α 1 -R Ab and of untreated DM rats. No marked abnormalities were observed in the renal tissue of healthy blank controls. Furthermore, in DM rats treated with α 1 -R Ab mediation + doxazosin intervention, the expression of TGF-β 1 significantly decreased, and renal functions and renal matrix remodeling were significantly improved, relative to untreated DM controls (P&lt;0.01). These results suggest that α 1 -R Ab may be involved in renal matrix remodeling during DM, and that kidney protection during DM may be achieved through treatment with corresponding receptor antagonists.

Doxazosin attenuates renal matrix remodeling mediated by anti-α1-adrenergic receptor antibody in a rat model of diabetes mellitus