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The present study investigated the application of the T 1ρ and T 2 relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the evaluation of intervertebral disc degeneration (IDD). A total of 93 asymptomatic subjects were imaged with T 1ρ and T 2 mapping, as well as DWI. Pfirrmann grading was performed and correlation analysis was conducted for T 1ρ , T 2 and DWI results with the grading results and age. Pfirrmann grading indicated 69 cases of grade I, 240 cases of grade II, 101 cases of grade III, 43 cases of grade IV and 12 cases of grade V. MRI showed that the T 1ρ values of the nucleus pulposi at L4/5 and L5/S1 were significantly reduced (P&lt;0.05) and no significant differences were observed in the T 2 values compared with the values of the nucleus pulposus at L1/2, L2/3 and L3/4. The apparent diffusion coefficient (ADC) values of L1/2 were significantly decreased from L2/3 and L3/4 (P&lt;0.05). Correlation analysis revealed that the T 1ρ , T, and ADC values were positively correlated with each other. Moreover, the T 1ρ values were significantly decreased with the increase of Pfirrmann grades (P&lt;0.05), with the exception of grades IV and V. However, T 2 and ADC values were not significantly different between grades I and II or IV and V. In addition, the T 1ρ , T 2 and ADC values were significantly decreased with the increase of age in patients with IDD (P&lt;0.05). T 1ρ and T 2 mapping and DWI are promising techniques for the in vivo diagnosis of IDD, which may be useful in determining the appropriate prevention and treatment options for the disease.

Multimodal quantitative magnetic resonance imaging for lumbar intervertebral disc degeneration