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There are trace amounts of heavy metals in cosmetics. Heavy metals such as mercury (Hg), which is added to skin-whitening cosmetics, may cause acute or chronic damage to human cells. The aim of this study was to investigate the cytotoxicity of mercury chloride (HgCl 2 ) to human keratinocytes. The keratinocytes were treated with various concentrations of HgCl 2 and the cell survival fractions were found to be 38.08, 17.59, 12.76, 3.29 and 0.77% when the cells were treated with 0.25, 0.5, 0.75, 1 and 1.5 μ M of HgCl 2 , respectively. Moreover, we observed that the greatest damage was to the cell membrane. The metallothionein (MT) protein expression was also investigated. MT expression levels increased with increasing concentrations of HgCl 2 . The results indicated that MT protects the keratinocytes against HgCl 2 -induced toxicity.

The cytotoxicity of mercury chloride to the keratinocytes is associated with metallothionein expression