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The Vitamin D receptor (VDR) gene has been implicated as one of the major genetic components of osteoporosis. We evaluated the relationship between the polymorphism in the VDR gene and the bone mineral density (BMD) of second metacarpus. The Fokl and Bsml genotypes were determined in 109 and 108 premenopausal Inner Mongolian women (35 49 years old), respectively. The BMD of second metacarpus was measured by computed X-ray densitometry(CXD). The bone-alkaline phosphatase (B-Alp) as a marker of bone formation, crosslaps (CL/Cr)as a marker of bone resorption, 25OHD, 1, 25 (OH) 2D3, body mass index (BMI), grip power and intakeof calcium were also measured. With regard to the distribution of Foki in 109 women, 58 (53.2%) women were "FF", 45 (41.3%) women were "Ff" and 6 (5.5%) women were "if". The composition of Bsml genotype in 108 women was 87 (80.6%) for "bb", 18 (16.7%) for "Bb" and 3 (2.8%) for "BB", respectively. The GS/D (BMD of second metacarpus bone), GSmax (BMD of bone cortex of second metacarpus) and GSmin (BMD of bone marrow of second metacarpus) of non-dominant hand with FF genotype were significantly higher than those with ff genotype (2.77 ± 0.23 vs 2.46 ± 0.23 Almm; 3.79 ± 0.28 vs 3.36 ± 0.30 Almm; 2.77 ± 0.34 vs 2.40 ± 0.41 Almm, p < 0.05, respectively). The GS/D and GSmax of dominant hand with FF genotype were significantly higher than those with ff genotype (2.80 ± 0.20 vs 2.51 ± 0.20 Almm; 3.82 ± 0.25 vs 3.46 ± 0.26 Almm, p < 0.05, respectively). GSmin of dominant hand with FF genotype was higher than that with ff genotype (2.77 ± 0.32 vs 2.46 ± 0.44 Almm, p < 0.1). The markers of bone metabolism, 25OHD, 1, 25 (OH) 2D3, BMI, grip power and intake of calcium showed no difference by Foki genotype. The BMD did not show any significant difference among Bsml genotype in premenopausal women in Inner Mongolia. There were no statistically significant interactions to those parameter of bone density between the Foki and Bsml genotypes. These findings suggest that BMD of second metacarpus may be related to Foki genotypes, although there were no evidences that Bsml genotype was associated with BMD of second metacarpus.

The associations between vitamin D receptor gene polymorphism and bone mineral density of second metacarpus in premenopausal women in Inner Mongolia.