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In HBV-infected patients, hepatitis B e antigen (HBeAg) seroconversion is associated with better outcomes. Interleukin-18 (IL-18) controls hepatitis B replication in a mouse model. However, its role in treatment response in HIV-HBV-coinfected patients is unknown.

Elevated Pre-Treatment IL-18 Level is associated with HBeAg Seroconversion in HIV-HBV Coinfection