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We present an implementation of the Gehrels et al. (2016) galaxy-targetedstrategy for gravitational-wave (GW) follow-up using the Las CumbresObservatory global network of telescopes. We use the Galaxy List for theAdvanced Detector Era (GLADE) galaxy catalog, which we show is complete (withrespect to a Schechter function) out to ~300 Mpc for galaxies brighter than themedian Schechter function galaxy luminosity. We use a prioritization algorithmto select the galaxies with the highest chance of containing the counterpartgiven their luminosity, their position, and their distance relative to a GWlocalization, and in which we are most likely to detect a counterpart given itsexpected brightness compared to the limiting magnitude of our telescopes. Thisalgorithm can be easily adapted to any expected transient parameters andtelescopes. We implemented this strategy during the second Advanced DetectorObserving Run (O2) and followed the black hole merger GW170814 and the neutronstar merger GW170817. For the latter, we identified an opticalkilonova/macronova counterpart thanks to our algorithm selecting the correcthost galaxy fifth in its ranked list among 182 galaxies we identified in theLaser Interferometer Gravitational-wave Observatory LIGO-Virgo localization.This also allowed us to obtain some of the earliest observations of the firstoptical transient ever triggered by a GW detection (as presented in a companionpaper).

Optical Follow-up of Gravitational-wave Events with Las Cumbres Observatory