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We study the distribution of the interstellar neutral (ISN) gas density andthe pick-up ion (PUI) density of hydrogen, helium, neon, and oxygen in theheliosphere for heliocentric distances from inside 1 au up to the solar windtermination shock (TS), both in and out of the ecliptic plane. We discusssimilarities and differences in the large-scale structures of the ISN gas andPUIs formed in the heliosphere between various species. We discuss thedistribution of ISN gas and PUI densities for two extreme phases of the solaractivity cycle, it is the solar minimum and the solar maximum. We identify thelocation of the ISN gas density cavity of various species. We study therelative abundance ratios of Ne/O, H/He, Ne/He, and O/He for ISN gas and PUIsdensities and their variation with location in the heliosphere. We also discussthe modulation of relative abundance ratios of ISN gas and PUIs along the TS.We conclude that the preferable locations for detection of He$^+$ and Ne$^+$PUIs are in the downwind hemisphere within 1~au, whereas for H$^+$ and O$^+$PUIs the preferable locations for detection are for distances from Jupiter toPluto orbits.

Interstellar Neutral Gas Species And Their Pickup Ions Inside The Heliospheric Termination Shock. The Large-scale Structures