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Problem statement: Evaluate the effects of daily administration of L-carnitine and&#13; cinnamon extract for two weeks on the expression of Insulin-like Growth Factor-1 (IGF-1) and&#13; inducible Nitric Oxide Synthase (iNOS) genes in cardiac and brain tissues of rats with Insulin&#13; Resistance (IR). Approach: Rats were divided into 4 groups (8 animals each): Group (1) rats fed&#13; control diet (60% starch) as control while groups (2, 3 and 4) fed high fructose diet (60% fructose). At&#13; the beginning of the 3rd week of feeding, rats of group (3) were treated with L-carnitine (300 mg kg-1&#13; body weight/day, i.p.) and animals of group (4) received a daily oral dose of cinnamon aqueous extract&#13; (0.5 mL rat-1). The animals were maintained in their respective groups for 4 weeks. Results:&#13; Feeding high fructose diet causes significant reduction in Insulin Receptor Substrate-1 (IRS-1)&#13; (amounted 30.65%) and elevation in iNOS expression (reached 51%) in the cardiac tissues as&#13; compared to control. In brain tissues, the IGF-1 mRNA was reduced in fructose loaded groups&#13; (28.81%). Administration of either L-carnitine or cinnamon extract significantly improves the&#13; expression of the cardiac studied genes but with no effects on the brain tissues. Conclusion: The&#13; present study illustrated that CE was more potent than L-carnitine in improving the IR

american journal of biochemistry and biotechnology/american journal of biochemistry and biotechnology

Impact of L-Carnitine and Cinnamon on Insulin-Like Growth Factor-1 and Inducible Nitric Oxide Synthase Gene Expression in Heart and Brain of Insulin Resistant Rats