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Problem statement: It has been reported that genes expression (inducible Nitric Oxide&#13; (iNOS). Insulin-like Growth Factor-1(IGF-1) have a role in both glucose homeostasis and insulin&#13; resistance. The aim of this study was designed to evaluate the amelioration of the iNOS, IGF-1&#13; genes expression as well as IRS-1 in liver tissues of rats fed high fructose diet treated with Lcarnitine.&#13; Approach: About 24 male Wister rats of body weight 120-160 g were divided into 3 groups&#13; of 8 rats each. Group 1 received control diet, while group 2 and 3, rats received high fructose diet (60 g&#13; 100 g-1 diet). Group 3, after 2 weeks from fructose feeding animals were treated with L-carnitine (CA)&#13; (300 mg kg-1 body weight day-1 i. p). At the end of the experimental period (30 days), serum levels of&#13; glucose, insulin, Triacylglycerol (TG) and cholesterol were determined. Hepatic contents of&#13; cholesterol, triacylglycerol, Malondialdehyde (MDA) and nitrogen oxide products were assayed.&#13; Genes expressions of iNOS, IGF-1 as well as IRS-1 were also determined in liver tissues of the&#13; experimental animals feeding high fructose diet. Results: Compared to control rats, the high fructose&#13; feeding in animals induces alterations in serum glucose, lipid metabolism and hepatic TG and MDA.&#13; In addition, fructose fed group develop marked increase in hepatic gene expression of iNOS and&#13; pronounced decreases in both IGF-1 mRNA and IRS-1 receptor. The administration of L-carnitine to&#13; rats fed high fructose diet mitigated the adverse effects of fructose load (insulin resistance) through the&#13; regulation of studied genes expression as well as insulin receptor substrate-1. Conclusion: The&#13; important findings of this context indicate the close association between hepatic gene expression&#13; (iNOS and IGF-1), IRS-1 receptor and insulin resistance. The exogenous CA to fructose fed rats&#13; improves the inflammation resulting from insulin resistance through the amelioration of the studied&#13; genes expression. This indicates that iNOS and IGF-1 have the characteristics to be marker of the&#13; metabolic syndrome

american journal of biochemistry and biotechnology/american journal of biochemistry and biotechnology

Amelioration of Inducible Nitric Oxide Synthase, Insulin like Growth Factor-1 Gene Expression and Insulin Receptor Substrate-1 in Liver Tissue of Insulin Resistant Rats Treated With L-Carnitine