English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Problem statement: The role of 5-HT has been investigated in many behavioral activities.&#13; Thus, studies using raphe lesion showed that 5-HT is involved in sleep, general activity levels,&#13; habituation, aggression, pain sensitivity and morphine analgesia, avoidance behavior, self-stimulation&#13; and water consumption. Approach: The metabolic interaction between serotonin (5-&#13; hydroxytrptamine) and indole-3-aldehyde and xanthine via aldehyde oxidase (EC 1.2.3.1) and xanthine&#13; oxidase (EC 1.1.3.22), respectively, were studied in liver tissue homogenate of Dunkin-Hartley guinea&#13; pigs by following the decrease in substrate concentration using spectrophotometer. Homogenates of&#13; liver were incubated with indole-3-aldehyde in the presence and absence of serotonin or&#13; (chlorpromazine and allopurinol a potent and selective inhibitors for aldehyde oxidase and xanthine&#13; oxidase, respectively). Oxidation of indole-3-aldehyde to indole-3-acetic acid was reduced up to 63.2%&#13; in the presence of serotonin (100 µM), while oxidation of xanthine to uric acid was reduced up to&#13; 51.6% under the same conditions. Results: In comparison, incubation of the substrates with their&#13; specific inhibitors (100 µM of chlorpromazine and 100 µM allopurinol) give almost complete&#13; inhibition. These results demonstrate that in the guinea pig liver a metabolic interaction between&#13; serotonin and indole-3-aldehyde or xanthine via molybdenum hydroxylases system may take place in&#13; liver, which is the main tissue for xenobiotics detoxification. Conclusion: The overall conclusion from&#13; this research is that serotonin could be a protector for neurons and other tissue from the insult of oxidation&#13; of aldehydes and xanthines by molybdenum hydroxylases

american journal of biochemistry and biotechnology/american journal of biochemistry and biotechnology

&lt;i&gt;In Vitro&lt;/i&gt; Interaction of 5-Hydroxytrptamine with Cytosolic Molybdenum Hydroxylases as a Potential Inhibitor for Initial Rates Activities