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Problem statement: The goal of the current investigation was to clarify the effects of&#13; Citrullus colocynthis pulp extract on the structure of the liver of diabetic rats at both light and scanning&#13; electron microscopic levels. Approach: Forty-eight adult male albino rats were equally allocated into&#13; four groups: Group1: control, Group 2: Citrullus colocynthis-treated, Group 3: diabetic rats and&#13; Group4: diabetic rats treated with Citrullus colocynthis. All treatments were administered via an&#13; intragastric tube. Diabetes was induced in the rats of groups 3 and 4 by an intraperitoneal injection&#13; with alloxan. Results: The liver of Citrullus colocynthis-treated rats revealed minor histological&#13; changes versus the control animals. In group 3 animals, diabetes caused degenerative alterations in the&#13; form of disorganization of the hepatic cords, cytoplasmic vacuolization and pyknosis of the nuclei of&#13; hepatocytes and inflammatory cell infiltration. Scanning electron microscope examination of these livers&#13; revealed numerous lipid droplets within hepatocytes, damaged blood sinusoids and hemorrhage of&#13; erythrocytes between hepatocytes and inside Disses spaces. On the other hand, the normal histological&#13; and scanning ultrastructural features were nearly resumed in the liver of diabetic rats treated with&#13; Citrullus colocynthis pulp extract. Conclusion: The present study proved a lessening effect of Citrullus&#13; colocynthis pulp extract on the liver of diabetic rats. In light of these advantageous influences, it is&#13; advisable to widen the scale of its use in a trial to alleviate the diabetic hepatic adverse effects

The Effect of <i>Citrullus colocynthis</i> Pulp Extract on the Liver of Diabetic Rats a Light and Scanning Electron Microscopic Study