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Problem statement: A goal during weight loss is to reduce body fat while maintaining&#13; body protein. We hypothesized that an increased dietary lysine: calorie might be beneficial during&#13; periods of caloric restriction. Approach: Two experiments were conducted to determine if changing&#13; the ratio of lysine: calories (lysine g/kg: Mcal ME/kg) while maintaining an ideal profile of amino&#13; acids will change nitrogen metabolism and weight loss in obese mature dogs. Results: The results of&#13; these experiments imply that if all essential amino acids are in adequate supply in the food, foods with&#13; an optimal balance of nutrients can reduce muscle degradation during periods of caloric restriction.&#13; Conclusion: Our optimum food for decreasing protein degradation was the food containing 3.0 lysine:&#13; calorie. However, the present experiments were relatively short and these results may not be sustained&#13; over longer periods of restriction

Dietary Lysine: Calorie Ratios and Their Influence on Nitrogen Metabolism and Digestibility in Moderately Obese Mature Dogs