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Abstract Rhodiola sachalinensis A. Bor is a plant naturally grows in ahigh mountain areas. Aim of this study was to evaluate the effects ofR.sachalinensis A. Bor extract against excessive exercise induced stress.R.sachalinensis A. Bor extract significantly inhibited L6 muscle celldeath and ATP reduction caused by H 2 O 2 damage. In addition, the oraladministration of R. sachalinensis A. Bor extract in mice improved the43.9% of treadmill running time and blood profiles of glutamicoxaloacetic transaminase, glutamic pyruvic transaminase, lactatedehydrogenase, creatinine, lactate when compared to distilled water.These results suggested that R. sachalinensis A. Bor can attenuateexcessive exercise induced damage.Keywords ATP · exercise · hodiola sachalinensis A. Bor · L6   , , , ,,         (Bassuk and Manson, 2005; Roberts and Barnard, 2005).                (Ji, 1996;Hyun, 2009).  super-oxide radical, hydroxyl radical,hydrogen peroxide, singlet oxygen     ,      ,           DNA   (Djordjevi, 2004).      superoxide reductase,catalase, glutathione peroxidase           (Irshad and Chaudhuri, 2002; Urso and Clarkson,2003).       C,β-caroten   .(Rhodiola sachalinensis A. Bor)    (Angiospermae) (Crassulaceae) (Rhodiola)       1,700−2,300 m    .     salidroside,tyrosol     , ,    , , , ,     (Bae, 2005; Lee , 2005; Park ,2005; Li , 2008).  Ryu (2008), Lee (2009) Jung(2008)      IEGs        Tradmill     .         L6 muscle cell          .       Tradmill            .   .  2010

Protective Effect of Rhodiola sachalinensis A. Bor on Excessive Exercise Stress