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Monascus pilosus       ICR            . (NC), (HC),   2%  (CHA)  M. pilosus    2%  (mCHA)  7 .  CHA mCHA    HC   24.15  29.66%    .       CHA  mCHA HC  .     mCHA  .  TG   mCHA NC  . CHA mCHA HDL-cholesterol  HC  96.55  119.32% . CHA mCHA CHA  mCHA LDL-cholesterol   0.67  0.41 .   GSH  HC  CHA 11.24%, mCHA 23.68% . LPO  CHA mCHA HC  43.70  45.38% . CHA mCHA xanthine oxidoreductase D type  HC   18.52  33.33%  mCHA NC  . XOD O type  CHA mCHA HC   16.67  33.33% . superoxide dismutase  CHA mCHA HC   . mCHA glutathione S-transferase  HC    , mCHA glutathione peroxidase  HC 2.55, CHA 1.5  NC . CHA mCHA ALT  HC   .    , CHA mCHA         ,          .    M. pilosus                  . 【The anti-obese, hypolipidemic and hepatoprotective effects of post-fermented green tea by Monascus pilosus was tested with mice fed with high-fat diet for 7 weeks. The body weight gain and feed efficiency ratio (FER) in normal control group (NC), CHA (2% non-fermented green tea powder supplemented high-fat diet group) and mCHA (2% green tea powder post-fermented by M. pilosus supplemented high fat diet group) groups were significantly lower than those of high fat diet control group (HC). Epididymal fat weight in mCHA and NC were significantly lower than HC. The hepatic lipid peroxide was dramatically higher in HC than that of NC and was significantly lower in CHA and mCHA. In addition, dehydrogenase type activity of xanthine oxidoreductase in HC was lower than that of NC, but significantly higher than CHA and mCHA. In histopathological findings, hepatic fat accumulation in HC was higher than that of NC, CHA and mCHA. Antiobese, hypolipidemic and antifatty liver effect of green tea powder post-fermented by M. pilosus was slightly higher than that of non-fermented green tea. In conclusion, the constituents of green tea fermented by M. pilosus has been proven to not only inhibit obesity and hyperlipidemia but also decrease the hepatic fat accumulation in high fat diet-induced obese mice.】

journal of applied biological chemistry

Dietary Effects of Post-fermented Green Tea by Monascus pilosus on the Body Weight, Serum Lipid Profiles and the Activities of Hepatic Antioxidative Enzymes in Mouse Fed a High Fat Diet