Efficacy of Platelet Rich Plasma (PRP) Gel in Bone Regeneration of Periapical Cystic Lesion

Objective: To evaluate the efficacy of Platelet rich plasma gel in bone regeneration of periapical cystic lesion. Study Design: Experimental case series. Place and Duration of Study: Oral & Maxillofacial Surgery Department, Institute of Dentistry, Liaquat University of Medical & Health Sciences, Jamshoro/ Hyderabad, from May 2017 to January 2018. Methodology: Data was collected from Outpatient Department patients of Oral & Maxillofacial Surgery Department, Liaquat University of Medical & Health Sciences Jamshoro/Hyderabad who fulfilling the inclusion criteria. Root canal therapy of involved tooth. After that Blood sample of patient with help of 10cc disposable syringe and draw 10 ml blood intravenously. For 10 minutes blood sample was centrifuged and then Platelet rich plasma gel formed. After getting the gel is stable within anti-cogulated condition and stored as 8 hours at room temperature. With the help of 18-gauge needle Platelet rich plasma gel will subsequently introduced immediately into the bone cavity to fill up the empty space completely. Platelet-rich rich plasma (PRP) gel application and assessed the measurement on pre and post periapical radiograph that is with the help of ruler will recorded on proforma at 2nd week, 4th week, 12 weeks, and 24th week Results: The total number 45 patients were included in this study to treat the periapical cystic lesion with Platelet rich plasma gel for healing. Mean defect size was 3.88±1.25cm after 1st week it was observed 3.19±1.06cm than at 4th week followup it was 2.46±0.87cm and at 12th weeks defect size was 1.39±0.61cm it was also reduced at 24th week which was observed in 0.53±0.32cm. At 24 weeks mean defect done fill was 95.95±1.91% which is showing rapid healing. Conclusion: The result of this study concluded that platelet rich plasma gel (PRP gel) was highly effective in healing of cystic bony defect resulting from enucleation of periapical cyst in speedy motion by clinically and radiographically.