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Mechanochemical synthesis of Co(II) and Cu(II) aspirin complexes was carried out by simple grinding of metal (II) acetates with aspirin without any solvent. Also conventional preparation of the above complexes was carried out for comparison purposes using the solution-based method. The products of mechanochemical synthesis were characterized by comparison of solubility, melting points, conductivity values, magnetic moment and IR analyses with those of ligands and conventional solution-based products. The IR spectral and analytical data of the complexes were similar for both products of the two synthetic routes suggesting the formation of identical compounds. Job’s method analyses suggested 1:2 metal to ligand ratio. The elemental analyses results revealed identical percentage composition of each element found in the products as compared to those of calculated percentages. The complexes have low values of molar conductance (4.24-6.60Ωcmmol) implying that they are non-electrolytes in DMSO. The complexes were all soluble in dimethylformamide and dimethylsulfoxide. The complexes were mostly soluble in non-polar solvents. All the products decomposed at a temperature range of 177.0-181.9C higher than that of their ligand revealing their more stable nature. The magnetic moment values obtained proved the paramagnetic nature of the synthesized complexes. The products and the ligand were screened against three bacteria isolates; Escherichia coli, Kledsiella pneumonia, Staphylococcus aureus and two fungi isolates; Aspergillus fumigatus, Mucus specie for antimicrobial activity. The results shows that the ligand was inactive against all the test organisms; the complexes were active in all test concentration, with only Co(asp)2 complex inactive against Staphylococcus Aureus at a concentration of 15μg/disc.

Alternative Synthetic Method and Antimicrobial Activity Screening of Co (II) and Cu (II) Complexes of 2-(Acetyloxy) Benzoic Acid (Aspirin)