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Globally Anaemia is a public health hurdle influencing both developing and developed countries at all ages. World Health Organization (WHO) defines Anaemia as the hemoglobin (Hb) levels <12.0 g/dl in women and <13.0 g/dl in men. Etiology of Anaemia is often multi factorial. Among those, prolonged use of acid suppressants in hospitalized, ambulatory and non ambulatory patient setting is a notorious one. Acid suppressants are the therapeutic agents which prove to be effective in the treatment of common gastro intestinal disorders like peptic ulcer, Gastro Esophageal Reflux Disease etc. Acid suppressants can be classified into three pharmacological classes namely histamine-2 receptor antagonists, proton pump inhibitors and miscellaneous. These are often used for prolonged period of time in many a circumstances to inhibit the secretion of gastric acid. The gastric acid is necessary for the absorption of Vitamin-B 12 and Iron. This paves the way for the incidence of Iron and Vitamin-B12 deficiency Anaemia in some patients as an adverse effect. This review exemplifies the mechanism associated with this and also compares the results of various research works, case reports those are similar to this topic. It also sheds light towards the clinical management of different types of Anaemia induced by persistent use of acid suppressants.

A Review on Vitamin B12 and Iron Deficiency Anaemia Linked with Persistent Use of Gastric Acid Suppressants