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8   , , ,          .            [1].        ,        ,    cytokine (adipocytokine)       .    (leptin)[2], tumor-necrosis factor-[3], plasma activator inhibitor type 1[4], adipsin[5], resistin[6],  (adiponectin)[7]  .  apM1 (adipose most abundant gene transcript 1)        ,   adipocytokine  .      [8].  2         [9],           (anti-atherogenic)      [10].      (antiinflammatory)          [11~13].       cytokine  [11], nuclear factor B  [14],   (foam cell)     [15].     ,        .    missense mutation      ,             [16].      (neointima)        knockout-mice         [13].                      .   apM1 3   27  , 3  2   [17].     (mutation)  ,  R112C, I164T, R221S  H241P  globular domain missense mutation 45, 94, 276, -11391, -11377 G/T    (single-nucleotide polymorphism, SNP)   .     I164T [18] SNP94[19], SNP276[19]

The Role of Polymorphism of Adiponectin Gene in the Atherosclerosis