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Resveratrol (RSV) is a naturally occurring polyphenol that has been shown to have a wide range of biological activities, including phytoestrogenic, antioxidant, anti-inflammatory, anti-cancer, and anti-aging functions [1,2,3]. Several studies have proposed that RSV has beneficial effects on obesity and diabetes, such as decreased adipogenesis and viability in maturing preadipocytes, and increased lipolysis and decreased lipogenesis in mature adipocytes [2,4]. Treatment with RSV in mice ameliorated insulin resistance and increased resistance to cold [4]. The beneficial effects of RSV have been largely attributed to the ability of RSV to enhance energy expenditure by boosting mitochondrial function as a result of increased levels of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and uncoupling protein 1 (UCP-1) in skeletal muscles and brown adipose tissue (BAT) [4].

endocrinology and metabolism

Letter: The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes (Endocrinol Metab2016;31:328-35, Cheol Ryong Ku et al.)