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Introduction. Oncological diseases take the second place in the world in mortality rate after cardiovascular pathology. the development of the tumor is accompanied by the appearance and accumulation of a number of pathological metabolites. At the same time, it is worth noting that the expansion of indications for the use of surgical methods of treatment, as well as an increase in the range of medicated antitumor drugs, especially against the background of combination therapy, is still accompanied by aggressive effects on the patient's body. thus, the consequences of radiation and chemotherapy are quite significant and consist of the cumulation of cytotoxic drugs that are toxic not only for tumor cells, but also for other tissue structures of the body. In this connection, intensive therapy of endogenous intoxication in case of tumor lesions is one of the complex interdisciplinary problems, in which should participate surgeons, resuscitators, pathophysiologists, transfusiologists.

Background to the Use of Plasmapheresis in Complex Therapy and Rehabilitation of Oncologic Patients