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The bicyclic bases 4-(dimethylamino)-6,7-diphenylbicyclo[2.2.2]octan-2-ol 1e and N,N-dimethyl-7,8-diphenyl-2-azabicyclo[3.2.2]nonan-5-amine 2e exhibit distinct activity against Plasmodium falciparum and Trypanosoma b. rhodesiense [1, 2].[...]

SARs of the Antiprotozoal Potency of Diaryl Substituted Bicyclic Bases