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The stability of aqueous solutions of meloxicam is studied with samples of different concentrations, and in different containers. Quantitation is carried out utilizing a validated stability indicating HPLC assay with five-point calibration. Sample solutions of meloxicam of three different concentrations (2 mg ml−1; 250 µg ml−1; 40 µg ml−1) are subjected to simulated sunlight and tested for stability. A distinct correlation of the photodegradation rate with the concentration of the sample solution was found. Furthermore, the influence of size and geometry of the containers in which the solutions were exposed to light was investigated and results compared.

A VALIDATED HPLC-ASSAY FOR THE DETERMINATION OF MELOXICAM IN PRESENCE OF ITS DEGRADATION PRODUCTS