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The synthesis of a novel quinazolinone was accomplished by the reaction of quinazolin- 2,4-(1H,3H)-dione with trifluoromethanesulfonic anhydride in triethylamine. The antimicrobial activity was determined against eight microorganisms. The organisms were all susceptible to 3-(4-methoxyquinazolin-2-yl)-quinazolin-2,4-(1H,3H)-dione 3 at the concentrations used. The gram positive organisms showed more susceptibility than the gram negative ones.

Triflate-mediated Synthesis of 3-(4-Methoxyquinazolin-2-yl)- quinazolin-2,4-(1H,3H)-dione and its Antimicrobial Activity.