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2-phenyl-(3,4-dihydro-4-oxoquinazolin-3-yalc)e to acetamides (1&amp;2) and their B-(4-substituted phenyl) azo derivatives (3-10) were evaluated for their analgesic and antiinflammatory activities. The bromophenyl azo derivative (4) showed significant activity as comparable to standard drugs viz pentazocine, aspirin and other compounds exhibited moderate activities. All the synthesized compounds were tested for their toxicity have not shown any abnormality up to 1500 mg/kg Body weight in experimental animals.

scientia pharmaceutica

ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF 2-PHENYL (6, 8-DISUBSTITUTED 3,4-DIHYDRO-4-OXOQUINAZLIN-3-YCL) ACETO ACETAMIDES AND THEIR ß (4-SUBSTITUTED PHENYL) AZO ANALOGS