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It this work was studied the influence of polyols (propylene glycol, glycerol and sorbitol) on the physicochemical parameters (partition coefficient and surface tension) and liberation from aqueous solutions with propylene glycol of two derivatives of phenylcarbamic acid. Studied parameters and liberation were influenced by the structure of the studied derivatives and with the type and concentration of polyols.

scientia pharmaceutica

Study of local anaesthetics. Part 172* Comparison of the influence of auxilliary substances on physicochemical parameters of two phenylcarbamic acid derivatives