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Authors’ Contributions 1 Conception & Study Design, Data Collection & Processing, Data Analysis and/or Interpretation. 2 Conception & Study Design, Drafting of Manuscript, Critical Review. 3 Data Collection & Processing, Data Analysis and/or Interpretation. 4 Drafting of Manuscript, Critical Review. 5 Data Analysis and/or Interpretation, Drafting of Manuscript. 6 Data Collection & Processing, Critical Review. Acknowledgement The authors thank the Department of Zoology, Government College University, Lahore, Pakistan for providing all facilities for the completion of this study. Article info. Received: September 02, 2020 Accepted: January 25, 2021 Funding Source: Nil Conflict of Interest: Nil Cite this article: Mughal TA, Ali S, Hassan A, Saleem MZ, Mumtaz S, Mumtaz S. Carbon Tetrachloride-Induced Hepatocellular Damage in Balb C Mice and Pharmacological Intervention by Extract of Daucus Carota. RADS J Pharm Pharm Sci. 2020; 8(4):1-9. *Address of Correspondence Author: dr.shaukatali@gcu.edu.pk Background: Present research was planned to examine the shielding effect of Daucus carota root extract pre-treatment on the carbon tetrachlorideinduced hepatotoxicity in Balb C mice. Objective: To cover the assessment of the enzymatic activity such as Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) and biochemical constituents like cholesterol, protein, lipids, glucose and urea contents in both the blood and liver while RNA and DNA substances exclusively in the liver. Setting: The induction of carbon tetrachloride (CCl4)-induced hepatotoxicity caused a rise in ALT of plasma and a decline in LDH. Method: The mice were treated with CCl4 and Daucus carota extract to check their effect on the level of biochemical constituents. Main Outcome Measure: Daucus carota extract pre-treatment obliterated CCl4-induced variations in the actions of enzymes. Results: cholesterol content decreased while glucose level increased in the blood. Glucose, lipids, cholesterol and urea in the liver were reduced while total protein level rose. Daucus carota extract pre-treatment also prohibited CCl4-induced variations in total protein contents, urea, glucose and lipids in the liver. CCl4 action caused huge hepatic damage. This was averted by Daucus carota extract. Conclusion: These outcomes reveal that Daucus carota root extract pretreatment inhibited hepatic damage induced by CCl4 in the mice model, which corroborates its defensive effects against hepatic damage produced by both non-oxidative and oxidative mechanisms.