English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Colorectal cancer (CRC) is a leading cause of cancer-related death. This present study aims to identify differentially expressed genes (DEGs) and significant pathways in CRC based on expression profile databases, which may provide evidence for better understanding of the pathogenic mechanism of CRC. Initially, microarray-based gene expression analysis was used to screen out DEGs in three CRC-related databases (GSE41328, GSE75970 and GSE89076). Then, Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed to explore the role of DEGs in CRC. Next, the weighted correlation network analysis (WGCNA), receiver operating characteristic (ROC) curve analysis and protein-protein interaction (PPI) network were conducted to reveal the central genes and pathways. Furthermore, the survival analysis and correlation analysis were also carried out. We found 1722 DEGs in 3 CRC-related databases, and these genes were enriched in biological regulation, metabolic process, cytokine receptor interaction, cell cycle and cAMP signaling pathways. Additionally, some of them have been uncovered to be closely associated with the development of CRC. Besides, six genes (CDK1, CCNA2, CCNB1, CDC20, CDC45 and CCNB2) were found to be highly expressed in CRC, and involved in CRC-associated signaling pathways, which may affect the development of CRC. ROC analysis further proved that these six genes could serve as potential biomarkers indicating CRC. This study deepens our understanding of the molecular mechanisms of CRC, which suggests that the DEGs and the central genes may contribute to the development of new strategies in CRC treatment.

Central Genes and Signaling Pathways in Colorectal Cancer Are Determined Based on Bioinformatics Analysis